• Stephan P Kloska, Tobias Fischer, Darius G Nabavi, Ralf Dittrich, Hendrik Ditt, Ernst Klotz, Roman Fischbach, E Bernd Ringelstein, and Walter Heindel.
• Department of Clinical Radiology, University of Muenster, Albert-Schweitzer-Str. 33, 48149 Muenster, Germany. kloska@uni-muenster.de
• Eur Radiol. 2007 Sep 1; 17 (9): 2352-8.

AbstractComputed tomography (CT) is still the primary imaging modality following acute stroke. To evaluate a prototype of software for the calculation of color-coded whole-brain perfused blood volume (PBV) images from CT angiography (CTA) and nonenhanced CT (NECT) scans, we studied 14 patients with suspected acute ischemia of the anterior cerebral circulation. PBV calculations were performed retrospectively. The detection rate of ischemic changes in the PBV images was compared with NECT. The volume of ischemic changes in PBV was correlated with the infarct volume on follow-up examination taking potential vessel recanalization into account. PBV demonstrated ischemic changes in 12/12 patients with proven infarction and was superior to NECT (8/12) in the detection of early ischemia. Moreover, PBV demonstrated the best correlation coefficient with the follow-up infarct volume (Pearson's R = 0.957; P = 0.003) for patients with proven recanalization of initially occluded cerebral arteries. In summary, PBV appears to be more accurate in the detection of early infarction compared to NECT and mainly visualizes the irreversibly damaged ischemic tissue.

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