• Yoshihisa Matsumoto, Minoru Iko, Masanori Tsutsumi, Takahumi Mitsutake, Ayumu Eto, Kouhei Nii, Kanji Nakai, Hiromichi Oishi, Hiroshi Aikawa, and Kiyoshi Kazekawa.
• Department of Neurosurgery, Tanushimaru Central Hospital, Kurume, Japan. Electronic address: fwip4873@mb.infoweb.ne.jp.
• J Stroke Cerebrovasc Dis. 2015 Jul 1; 24 (7): 1513-9.

BackgroundStent-assisted coil embolization is effective for intracranial aneurysms, especially for wide-necked aneurysms; however, the optimal antiplatelet regimens for postoperative ischemic events have not yet been established. We aimed at determining the efficacy and safety of a triple antiplatelet therapy regimen after intracranial stent-assisted coil embolization.MethodsWe retrospectively evaluated patients who underwent stent-assisted coil embolization for unruptured intracranial aneurysms or during the chronic phase of a ruptured intracranial aneurysm (≥ 4 weeks after subarachnoid hemorrhage onset). We recorded the incidence of ischemic and bleeding events 140 days postoperatively.ResultsWe assessed 79 cases in patients who received either dual (n = 51) or triple (n = 28) antiplatelet therapy. The duration of triple antiplatelet therapy was 49 ± 29 days. Seven patients in the dual group experienced postoperative ischemic events. Compared to the dual group, the triple group had a similar incidence of postoperative bleeding events but a significantly lower incidence of postoperative ischemic events (P < .05).ConclusionsTriple antiplatelet therapy had a significantly lower incidence of postoperative ischemic events and a similar incidence of postoperative bleeding events 140 days postoperatively.Copyright © 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved.

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