• Emin Kaya, Muzaffer Keklik, Mehmet Sencan, Mehmet Yilmaz, Ali Keskin, Ilhami Kiki, Mehmet Ali Erkurt, Serdar Sivgin, Serdal Korkmaz, Vahap Okan, Mehmet Hilmi Doğu, Ali Unal, Mustafa Cetin, Fevzi Altuntaş, and Osman Ilhan.
• Inonu University Medical School, Department of Hematology and Aphaeresis Unit, Malatya, Turkey. emin.kaya@inonu.edu.tr
• Transfus Apher Sci. 2013 Jun 1; 48 (3): 349-52.

AbstractTherapeutic plasma exchange (TPE), is a procedure, changing pathologic substances in the plasma of patients with replacement fluid. TPE has an increasing list of indications in recent years such as neurological, connective tissue, hematological, nephrological, endocrinological and metabolic disorders. We report our multicenter data about therapeutic plasma exchange in patients with neurological diseases. Six University Hospitals' aphaeresis units medical records about neurologic diseases were reviewed retrospectively. Hundred and fifteen patients and 771 TPE sessions from six aphaeresis units' were included to this study. Of the 115 patients, 53 (46%) were men and 62 (54%) were women. The median age was 50 (range: 5-85) years. Of these patients 58.3% were Guillain-Barre syndrome (GBS), 17.4% were acute disseminated encephalomyelitis (ADEM), 10.4% were chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), 7% were multiple sclerosis, 6.1% were myasthenia gravis (MG) and 0.9% were Wilson disease (WD). The median number of TPE sessions per patient was 5 (range 1-72). Human albumin was used as a replacement fluid in 66% and fresh frozen plasma was used in 34% of cases. TPE was done through central venous catheters in 66%, and peripheral venous access in 34% of patients. Some complications were seen in patients (18.3%) during TPE sessions. These complications were, complications related to catheter placement procedure (8.7%), hypotension (3.5%), hypocalcaemia (3.5%) and allergic reactions (1.7%). The complication ratios were 2.7% in total 771 TPE procedures. TPE procedure was terminated in 6% of sessions depending on these complications. Overall responses to TPE were noted in 89.5% of patients. In conclusion; Therapeutic plasma exchange is an effective treatment option in several neurologic diseases.Copyright © 2013 Elsevier Ltd. All rights reserved.

30 keywords...

hide…