• Trends Pharmacol. Sci. · Jan 2014

    Review

    Molecularly targeted cancer therapy: some lessons from the past decade.

    • Min Huang, Aijun Shen, Jian Ding, and Meiyu Geng.
    • Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
    • Trends Pharmacol. Sci. 2014 Jan 1; 35 (1): 41-50.

    AbstractThe tremendous advances achieved in the understanding of cancer biology have delivered unprecedented progress in molecularly targeted cancer therapy in the past decade. The fast growing category of targeted anticancer agents available for clinical use is accompanied by a conceptual revolution in anticancer drug development. Nevertheless, molecularly targeted cancer therapy remains challenged by a high failure rate and an extremely small proportion of patients that can benefit. It is pivotal to take lessons from the past and seek new solutions. This review discusses conceptual progress and remaining challenges in molecularly targeted cancer therapy, and proposes feasible alternatives to increase chances of clinical success in the future.Copyright © 2013 Elsevier Ltd. All rights reserved.

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