• J. Matern. Fetal. Neonatal. Med. · Jul 2006

    Neonatal outcome in polycystic ovarian syndrome patients treated with metformin during pregnancy.

    • Michal Kovo, Ariel Weissman, Dvir Gur, David Levran, Sigi Rotmensch, and Marek Glezerman.
    • Department of Obstetrics and Gynecology, The Edith Wolfson Medical Center, Holon, Israel. michalkovo@hotmail.com
    • J. Matern. Fetal. Neonatal. Med. 2006 Jul 1; 19 (7): 415-9.

    ObjectiveThe present study aimed to evaluate the effect of metformin exposure during pregnancy on neonates of polycystic ovarian syndrome (PCOS) patients.MethodNeonatal outcomes of 33 women with PCOS treated with metformin during pregnancy were compared to neonatal outcomes of 66 normal healthy women in a retrospective case-control study.ResultsThe mean birth weight percentile of neonates exposed to metformin in utero during the first trimester was significantly lower than that of neonates delivered to normal healthy matched controls. After controlling for pregnancy complications, this observation became only marginally statistically significant.ConclusionAlthough metformin is an attractive option for induction of ovulation in PCOS patients, there is a need for more evidence related to its safety during pregnancy.

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