• Anders Westanmo, Peter Marshall, Elzie Jones, Kevin Burns, and Erin E Krebs.
• Department of Pharmacy, Minneapolis VA Health Care System, Minneapolis, Minnesota, USA.
• Pain Med. 2015 May 1; 16 (5): 1019-26.

ObjectiveTo describe processes and outcomes of a health system quality improvement initiative designed to reduce opioid-related harms.DesignThe initiative was a primary care population-level intervention to reduce high-dose opioid prescribing, which was locally defined as >200 morphine-equivalent mg (MED) daily. We describe the implementation process and report prescribing rates and primary care provider (PCP) attitudes and beliefs before and after implementation.SettingA VA health care system comprising one large, urban teaching hospital and 11 outpatient clinics in surrounding suburban and rural locations.SubjectsAll patients who received any prescription from the outpatient pharmacy (unique pharmacy patients) were included in the population. PCPs at the main hospital were surveyed.MethodsPrescribing outcomes were determined from merged VA databases by examining rates of opioid dispensing within 90-day time windows before and after implementation. PCP beliefs and attitudes were evaluated with preimplementation and postimplementation surveys.ResultsFollowing implementation, the number of patients prescribed >200 MED daily decreased from 342 (0.65% of unique pharmacy patients) to 65 (0.12%). Overall, the number of unique pharmacy patients who received at least one opioid prescription within 90 days decreased from 6,942 (13.7%) on April 1, 2011 to 5,981 (11.0%) on October 1, 2014 (13.8% decrease). Most PCPs agreed it was reasonable for the medical center to set a 200 MED limit (76% at baseline and 87% at follow up).ConclusionOpioid Safety Initiative implementation was associated with a substantial reduction in high-dose opioid prescribing. Factors that contributed to initiative success included leadership support and active clinical pharmacy engagement.Wiley Periodicals, Inc.

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