• Br J Neurosurg · Apr 2011

    Case Reports

    Two cases of unexpected long-term improvement of Parkinson's disease after subthalamic nucleus deep brain stimulation removal.

    • S H Wong, P R Eldridge, A Duffy, S H Fox, T R K Varma, and N A Fletcher.
    • Departments of Neurology, The Walton Centre, Liverpool, UK. suiwong@doctors.org.uk
    • Br J Neurosurg. 2011 Apr 1; 25 (2): 281-3.

    AbstractTwo patients with Parkinson's disease (PD) treated successfully with subthalamic nucleus deep brain stimulation (STN-DBS) for 3-4 years are reported, who demonstrated a persistent improvement following removal of STN-DBS for late infection. Possible hypotheses are discussed--whether a microlesioning effect or a disease-modifying effect of STN-DBS, though neither adequately explain this phenomenon.

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