• Alzheimers Dement · Mar 2015

    Gender and incidence of dementia in the Framingham Heart Study from mid-adult life.

    • Geneviève Chêne, Alexa Beiser, Rhoda Au, Sarah R Preis, Philip A Wolf, Carole Dufouil, and Sudha Seshadri.
    • Inserm U897 and CIC-EC7; University of Bordeaux Segalen, Isped (Bordeaux School of Public Health), CHU de Bordeaux, Bordeaux, France. Electronic address: genevieve.chene@isped.u-bordeaux2.fr.
    • Alzheimers Dement. 2015 Mar 1; 11 (3): 310-20.

    BackgroundGender-specific risks for dementia and Alzheimer's disease (AD) starting in midlife remain largely unknown.MethodsProspectively ascertained dementia/AD and cause-specific mortality in Framingham Heart Study (FHS) participants was used to generate 10- to 50-year risk estimates of dementia/AD on the basis of the Kaplan-Meier method (cumulative incidence) or accounting for competing risk of death (lifetime risk [LTR]).ResultsOverall, 777 cases of incident dementia (601 AD) occurred in 7901 participants (4333 women) over 136,266 person-years. Whereas cumulative incidences were similar in women and men, LTRs were higher in women older than 85 years of age. LTR of dementia/AD at age 45 was 1 in 5 in women and 1 in 10 in men. Cardiovascular mortality was higher in men with rate ratios decreasing from approximately 6 at 45 to 54 years of age to less than 2 after age 65.ConclusionSelective survival of men with a healthier cardiovascular risk profile and hence lower propensity to dementia might partly explain the higher LTR of dementia/AD in women.Copyright © 2015 The Alzheimer's Association. All rights reserved.

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