• Free Radic. Biol. Med. · Jan 1991

    Thermodynamic considerations on the generation of hydroxyl radicals from nitrous oxide--no laughing matter.

    • W H Koppenol.
    • Department of Chemistry, Louisiana State University, Baton Rouge 70803-1800.
    • Free Radic. Biol. Med. 1991 Jan 1; 10 (1): 85-7.

    AbstractThe one-electron reduction of nitrous oxide is a possible pathway to the hydroxyl radical. The one- and two-electron reduction potentials EO' (N2O/OH,N2) and EO' (N2O/H2O, N2) are calculated to be 0.32 V and 1.32 V at pH 7, respectively, for all species dissolved in water. Although nitrous oxide is thermodynamically capable of oxidising a variety of biomolecules, it is kinetically rather inert. The reason that nitrous oxide does not produce hydroxyl radicals readily might be that the one-electron reduction proceeds through an N2O- intermediate which is energetically very unfavourable: EO (N2O/N2O-) = -1.1 V.

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