• Internal medicine · Jan 2008

    Review Case Reports

    Pancytopenia complicated with peripheral neuropathy due to copper deficiency: clinical diagnostic review.

    • Osamu Imataki, Hiroaki Ohnishi, Akira Kitanaka, Yoshitsugu Kubota, Toshihiko Ishida, and Terukazu Tanaka.
    • Division of Hematology, Faculty of Medicine, Kagawa University, Kagawa. oima@med.kagawa-u.ac.jp
    • Intern. Med. 2008 Jan 1; 47 (23): 2063-5.

    AbstractOnly a dozen cases of pancytopenia caused by copper deficiency have been reported. We report the case of an 81-year-old man who underwent total gastrectomy for gastric cancer. He received total parenteral nutrition without trace element supplementation for 6 months. Serum levels of copper and ceruloplasmin were low, but serum zinc was normal. The administration of copper into TPN led to rapid improvement in anemia and neutropenia. We review 11 previous cases of copper-deficient cytopenia, categorized into two groups according to etiology, and define the characteristic symptom of copper malabsorption caused by excess Zn as peripheral neuropathy.

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