• Ria Bhola, Evelyn Kinsella, Nicola Giffin, Sue Lipscombe, Fayyaz Ahmed, Mark Weatherall, and Peter J Goadsby.
• eNeura Therapeutics, Sunnyvale, CA, USA, rbhola@eneura.com.
• J Headache Pain. 2015 Jan 1; 16: 535535.

BackgroundSingle pulse transcranial magnetic stimulation (sTMS) is a novel treatment for acute migraine. Previous randomised controlled data demonstrated that sTMS is effective and well tolerated in the treatment of migraine with aura. The aim of the programme reported here was to evaluate patient responses in the setting of routine clinical practice.MethodsMigraine patients with and without aura treating with sTMS had an initial review (n = 426) and training call, and then participated in telephone surveys at week six (n = 331) and week 12 during a 3-month treatment period (n = 190).ResultsOf patients surveyed with 3 month data (n = 190; episodic, n = 59; chronic, n = 131), 62 % reported pain relief, finding the device effective at reducing or alleviating migraine pain; in addition there was relief reported of associated features: nausea- 52 %; photophobia- 55 %; and phonophobia- 53 %. At 3 months there was a reduction in monthly headache days for episodic migraine, from 12 (median, 8-13 IQ range) to 9 (4-12) and for chronic migraine, a reduction from 24 (median, 16-30 IQ range) to 16 (10-30). There were no serious or unanticipated adverse events.ConclusionsTMS may be a valuable addition to options for the treatment of both episodic and chronic migraine.

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