• Transfus Apher Sci · Dec 2008

    Review

    Role of nitric oxide in the prevention of severe adverse events associated with blood products.

    • C R Valeri and G Ragno.
    • Naval Blood Research Laboratory, 195 Bournehurst Drive, Plymouth, MA 02360, USA. navblood@nbrl.org
    • Transfus Apher Sci. 2008 Dec 1; 39 (3): 241-5.

    AbstractThe reduction in vitro of nitric oxide binding to the globin portion of hemoglobin (SNOHb) in fresh and liquid preserved red blood cells has been reported to be responsible for the severe adverse events (SAEs) associated with red blood cell transfusion. No in vivo data were reported that the reduction in SNOHb in red blood cells following transfusion was irreversible. In addition, no clinical data were reported that the reduction in SNOHb in red blood cells produced severe adverse events (SAEs) in recipients.

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