• Leukemia research · Jul 2001

    Review

    Treatment of mastocytosis: pharmacologic basis and current concepts.

    • G Marone, G Spadaro, F Granata, and M Triggiani.
    • Divisione di Immunologia Clinica e Allergologia, Università di Napoli Federico II, Facoltà di Medicina, Via S. Pansini 5, 80131 Naples, Italy. marone@unina.it
    • Leuk. Res. 2001 Jul 1; 25 (7): 583-94.

    AbstractMastocytosis is a rare, heterogeneous disorder characterized by a marked increase in mast cell density in various tissues. Mast cells from different human tissues are heterogeneous. So far, there is no cure for systemic mastocytosis. Conventional therapy is based on agents that antagonize mediators released from mast cells, drugs that inhibit the release of mediators and agents that modulate mast cell proliferation. This pharmacologic approach is satisfactory in the majority of patients with indolent mastocytosis. At the beginning of the new millennium, the therapy of severe forms of aggressive mastocytosis remains a challenge for students of this intriguing disorder.

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