• Andreas Brunauer, Andreas Koköfer, Otgon Bataar, Ilse Gradwohl-Matis, Daniel Dankl, Jan Bakker, and Martin W Dünser.
• Department of Anesthesiology, Perioperative and General Intensive Care Medicine, Salzburg University Hospital and Paracelsus Medical University, Salzburg, Austria.
• J Crit Care. 2016 Oct 1; 35: 105-9.

PurposeTo correlate clinical indicators of peripheral perfusion with visceral organ vascular tone in 30 septic shock patients.Materials And MethodsIn a prospective pilot study, capillary refill time, the Mottling score, and peripheral temperature were determined within 24, 48, and 72 hours after intensive care unit admission. Simultaneously, pulsatility indices in the liver, spleen, kidneys, and intestines were measured by Doppler ultrasonography. Correlation analyses were calculated, applying an adjusted significance level (P< .0125) to correct for multiple testing.ResultsSignificant relationships were observed between the pulsatility index of selected organs and the capillary refill time (intestines: r= 0.325, P= .007), and the Mottling score (kidneys: r= 0.396, P= .006), but not peripheral temperature (all r< 0.14, P> .05). An association over time was observed for the capillary refill time and pulsatility index of the liver (P= .04) and intestines (P= .03) as well as for the Mottling score and the kidneys' pulsatility index (P= .03), but not for peripheral temperature and any visceral organs' pulsatility index.ConclusionsCapillary refill time and skin mottling may be correlated with the pulsatility index, a sonographic surrogate of vascular tone, of visceral organs in early septic shock.Copyright © 2016 Elsevier Inc. All rights reserved.

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