• J Surg Oncol · Sep 2011

    Review

    The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery.

    • Boudewijn E Schaafsma, J Sven D Mieog, Merlijn Hutteman, Joost R van der Vorst, Peter J K Kuppen, Clemens W G M Löwik, John V Frangioni, Cornelis J H van de Velde, and Alexander L Vahrmeijer.
    • Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
    • J Surg Oncol. 2011 Sep 1; 104 (3): 323-32.

    AbstractOptical imaging using near-infrared (NIR) fluorescence provides new prospects for general and oncologic surgery. ICG is currently utilised in NIR fluorescence cancer-related surgery for three indications: sentinel lymph node (SLN) mapping, intraoperative identification of solid tumours, and angiography during reconstructive surgery. Therefore, understanding its advantages and limitations is of significant importance. Although non-targeted and non-conjugatable, ICG appears to be laying the foundation for more widespread use of NIR fluorescence-guided surgery.Copyright © 2011 Wiley-Liss, Inc.

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