• Pediatr Crit Care Me · Aug 2016

    Hypoplastic Left Heart Syndrome and Other Shunt-Dependent Single Ventricles.

    • Sarah Tabbutt, James S Tweddell, and Nancy Ghanayem.
    • 1Division of Cardiology and Critical Care Medicine, Department of Pediatrics, University of California San Francisco School of Medicine, University of California San Francisco, Benioff Children's Hospital, San Francisco, CA. 2Department of Surgery, Heart Institute, Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. 3Division of Critical Care Medicine, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, WI.
    • Pediatr Crit Care Me. 2016 Aug 1; 17 (8 Suppl 1): S318-22.

    ObjectivesIn this review, we discuss the pathophysiology, treatment, and outcomes of patients with the hypoplastic left heart syndrome and other single ventricle variants prior to and following surgery.Data SourceMEDLINE and PubMed.ConclusionsPatients with shunted single ventricle physiology are at increased risk for acute hemodynamic decompensation owing to the increased myocardial workload, the dynamic balance between systemic and pulmonary circulations, and the potential for shunt obstruction. Understanding of the physiology and anticipatory management are critical to prevent hemodynamic compromise and cardiac arrest.

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