• Int. J. Tuberc. Lung Dis. · Jan 2012

    Integrated detection of multi- and extensively drug-resistant tuberculosis using the nitrate reductase assay.

    • E Ramos, K Fissette, P de Rijk, J C Palomino, and A Martin.
    • Mycobacteriology Unit, Institute of Tropical Medicine, Antwerp, Belgium.
    • Int. J. Tuberc. Lung Dis. 2012 Jan 1; 16 (1): 110-3.

    AbstractIt currently takes 2-3 months to obtain a diagnosis for multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB). We evaluated the rapid non-commercial nitrate reductase assay (NRA), which is capable of the simultaneous detection of MDR- and XDR-TB, and compared the results with the proportion method (PM). The sensitivity was respectively 97%, 99%, 100% and 94.6% for rifampicin (RMP), isoniazid (INH), ofloxacin (OFX) and kanamycin (KM). The specificity was respectively 100%, 95%, 95.7% and 99% for RMP, INH, OFX and KM. The turnaround time for NRA was 10-14 days, compared to 4-6 weeks for the PM. Our study showed that NRA provided sensitive and specific detection of resistance to first- and second-line drugs.

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