• Int. J. Tuberc. Lung Dis. · Jun 2015

    Multicenter Study Comparative Study

    Pyrazinamide resistance in Mycobacterium tuberculosis arises after rifampicin and fluoroquinolone resistance.

    • A K Alame-Emane, P Xu, C Pierre-Audigier, V Cadet-Daniel, X Shen, M Sraouia, J F Djoba Siawaya, H Takiff, Q Gao, and B Gicquel.
    • Unité de Génétique Mycobactérienne, Institut Pasteur, Paris, France; Research and Specialised Diagnostics Unit, National Laboratory of Public Health, Libreville, Gabon.
    • Int. J. Tuberc. Lung Dis. 2015 Jun 1; 19 (6): 679-84.

    BackgroundMultidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (TB) constitute a major public health concern.ObjectiveTo determine the timing of pncA mutations that confer pyrazinamide (PZA) resistance in relation to mutations conferring resistance to isoniazid (INH) and rifampicin (RMP).DesignIsolates from two major urban centres--Paris (101 strains) and Shanghai (171 strains)--were investigated for the association of pncA mutations with resistance to drugs other than PZA.ResultsThe proportion of pncA mutations found in INH-monoresistant strains was not increased.ConclusionpncA mutations associated with PZA resistance were found almost exclusively in MDR-TB strains, underlining the importance of determining PZA resistance when treating MDR- or XDR-TB.

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