• J. Cardiothorac. Vasc. Anesth. · Oct 2016

    Outcome After General Anesthesia Versus Monitored Anesthesia Care in Transfemoral Transcatheter Aortic Valve Replacement.

    • Paola D'Errigo, Marco Ranucci, Remo Daniel Covello, Fausto Biancari, Stefano Rosato, Marco Barbanti, Francesco Onorati, Corrado Tamburino, Gennaro Santoro, Claudio Grossi, Francesco Santini, Katia Bontempi, Danilo Fusco, Fulvia Seccareccia, and OBSERVANT Research Group.
    • National Centre for Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanità, Rome, Italy.
    • J. Cardiothorac. Vasc. Anesth. 2016 Oct 1; 30 (5): 1238-43.

    ObjectiveTo evaluate outcomes of monitored anesthesia care (MAC) compared with general anesthesia (GA) in patients undergoing transfemoral transcatheter aortic valve replacement (TAVR).DesignSecondary analysis from the observational and prospective OBSERVANT (OBservational Study of Effectiveness of avR-taVi procedures for severe Aortic steNosis Treatment) study.SettingMulticenter study, including Italian hospitals performing TAVR interventions.ParticipantsOne thousand four hundred ninety-four patients with severe and symptomatic aortic stenosis.InterventionsTransfemoral TAVR under general or local anesthesia.Measurements And Main ResultsA propensity score procedure was applied, and 310 pairs were matched with similar baseline characteristics (EuroSCORE II: local anesthesia 6.6±5.9% v general anesthesia 7.0±7.7%, p = 0.430). MAC was associated with similar 30-day mortality compared with GA (3.9% v 4.8%, p = 0.564). TAVR was performed under MAC without any increased risk of other adverse events. The risk of paravalvular regurgitation≥mild was similar between the study groups (MAC 49.5% v general anesthesia 57.0%, p = 0.858). Two patients receiving on MAC had severe paravalvular regurgitation, whereas this complication was not observed after GA. Permanent pacemaker implantation was 19.1% in the MAC group v 14.8% in the GA group (p = 0.168). Mean intensive care unit stay was 3.5 days for the GA group v 2.9 days for the MAC group (p = 0.086). A similar 3-year survival rate was observed (MAC 69.4% v GA 69.9%, p = 0.966).ConclusionsTransfemoral TAVR can be performed under MAC with similar immediate and late outcomes as compared with GA. A possible risk of severe paravalvular regurgitation and pacemaker implantation with TAVR under MAC requires further investigation.Copyright © 2016 Elsevier Inc. All rights reserved.

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