• Curr. Opin. Neurol. · Jun 2009

    Review

    Improving the role of intraventricular antimicrobial agents in the management of meningitis.

    • Wendy C Ziai and John J Lewin.
    • Division of Neurosciences Critical Care, Department of Neurology and Anesthesiology-Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA. weziai@jhmi.edu
    • Curr. Opin. Neurol. 2009 Jun 1; 22 (3): 277-82.

    Purpose Of ReviewThe aim is to review the role of intraventricular administration of antimicrobial agents in the treatment of patients with bacterial and fungal meningitis.Recent FindingsThis article discusses indications for intraventricular antimicrobial agents, choice of antibiotics, strategies to monitor pharmacokinetics of central nervous system compartments and unanswered issues for this management approach.SummaryIntraventricular administration of antimicrobials may be necessary in certain difficult- to- eradicate central nervous system infections. There is a significant need for clinical trials and management guidelines in this area.

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