• Injury · Oct 2016

    Treatment of recalcitrant atrophic non-union of the humeral shaft with BMP-7, autologous bone graft and hydroxyapatite pellets.

    • Roberto Caterini, Vito Potenza, Ernesto Ippolito, and Pasquale Farsetti.
    • Department of Orthopaedic Surgery, University of Rome "Tor Vergata", Viale Oxford 81, Rome, 00133, Italy.
    • Injury. 2016 Oct 1; 47 Suppl 4: S71-S77.

    AbstractRecalcitrant humeral non-union is a disabling condition that is extremely difficult to treat. The use of BMP-7 has been proposed to improve bone healing. This is a report of the results obtained in 12 patients with recalcitrant humeral non-union treated using stable fixation with a long locking compression plate and BMP-7, autologous bone graft and hydroxyapatite pellets applied at the non-union site. Patients had up to three surgical attempts at non-union healing prior to our treatment. The average time from the initial fracture to our surgery was 5.2 years. Average follow-up was 5.3 years. At follow-up, non-union had healed in all patients by an average of 7.3 months. All the patients were very satisfied with their final results, despite a restricted range of motion of the elbow and a moderate muscular atrophy, which was frequently observed. Our study shows that BMP-7 associated with autologous bone grafting and hydroxyapatite pellets after stable fixation is an effective adjuvant to stimulate bone healing in the treatment of recalcitrant humeral non-union.Copyright © 2016 Elsevier Ltd. All rights reserved.

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