• Tiffany Y Kim, Kenneth A Woeber, Heidimarie Windham MacMaster, and Robert J Rushakoff.
• 1Department of Medicine, University of California, San Francisco, CA. 2Departments of Pharmacy and Nursing, University of California, San Francisco, CA.
• Crit. Care Med. 2016 Nov 1; 44 (11): e1137-e1140.

ObjectivesWe present the case of a 66-year-old woman who developed hypoglycemia following the prolonged infiltration of a high dose continuous peripheral IV insulin infusion.Study SelectionCase report.Data Sources And ExtractionPubMed was searched for relevant literature on exogenous hyperinsulinemic hypoglycemia.Data SynthesisThe patient was postlung transplantation and was receiving high doses of glucocorticoids. Despite increasing the peripheral IV insulin rate, hyperglycemia persisted. We discovered that the IV insulin infusion line infiltrated, resulting in a large subcutaneous insulin depot, estimated to be 450 units of regular insulin. She subsequently experienced prolonged hypoglycemia that was managed with concentrated dextrose containing fluids. In our literature search, there were no similar case reports. The literature on insulin overdose, usually from suicide attempts, can help guide the management of iatrogenic hyperinsulinemic hypoglycemia. Important management considerations include anticipated duration of hypoglycemia, supplemental glucose, fluid management, and electrolyte monitoring.ConclusionPeripheral IV insulin infusion infiltration should be considered when patients do not respond to increasing rates of insulin infusion.

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