• Alcohol. Clin. Exp. Res. · Oct 1980

    Ethanol oxidation by rat brain in vivo.

    • G Cohen, P M Sinet, and R Heikkila.
    • Alcohol. Clin. Exp. Res. 1980 Oct 1; 4 (4): 366-70.

    AbstractCan brain metabolize ethanol? We present data demonstrating that brain catalase in conjunction with endogenous H2O2 will oxidize ethanol in vivo. The method is based on an H2O2-dependent inhibition of brain catalase in vivo by 3-amino-1,2,4-triazole and its prevention by ethanol. The irreversible inhibition of catalase by aminotriazole is known to proceed via the reaction of (catalase-H2O2) compound I with aminotriazole. Inhibition can be prevented by compounds that are oxidized by compound I. Ethanol is one such compound. Prevention of the inhibition of brain catalase in vivo by prior administration of ethanol constitutes indirect evidence for the oxidation of ethanol to acetaldehyde in rat brain. The catalase content of the tissues represented catalase in the brain parenchyma, from which erythrocytes and capillaries had been excluded. Ethanol did not alter the levels of aminotriazole in brain. These results constitute the first demonstration of ethanol oxidation by living brain.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…