• Juan P Cata, Justin Jones, Boris Sepesi, Reza J Mehran, Andrea Rodriguez-Restrepo, Javier Lasala, Lei Feng, and Vijaya Gottumukkala.
• Departments of Anesthesiology and Perioperative Medicine; Anesthesiology and Surgical Oncology Research Group, Houston, TX. Electronic address: jcata@mdanderson.org.
• J. Cardiothorac. Vasc. Anesth. 2016 Aug 1; 30 (4): 930-5.

ObjectiveTo evaluate the association between the use of intraoperative dexamethasone with an increase in recurrence-free survival (RFS) and overall survival (OS) after non-small cell lung cancer (NSCLC) surgery.DesignThis was a propensity score-matched (PSM) retrospective study.SettingSingle academic center.ParticipantsThe study comprised patients with stage I through IIIa NSCLC. Patients were excluded if they were younger than 18 years, had missing data, and died within 30 days after surgery.Measurements And Main ResultsPrimary outcomes of the study were RFS and OS. The data were PSM. RFS and OS were evaluated using univariate and multivariate Cox proportional hazards models after PSM to assess the association between intraoperative dexamethasone use and the primary outcomes. A p value of<0.05 was considered statistically significant. After PSM, 436 patients were included in each treatment group. Adjusting for significant covariates, the multivariate analysis demonstrated no association between the use of dexamethasone and RFS (hazard ratio [95% confidence interval]: 0.98 [0.78-1.24]; p = 0.915). The multivariate analysis also demonstrated no association between the administration of dexamethasone and OS (hazard ratio [95% confidence interval]: 1.08 [0.81-1.44]; p = 0.58).ConclusionsThis study demonstrated that intraoperative dexamethasone administration to NSCLC patients was not associated with a significant impact on RFS and OS. The results were similar to a previous study on ovarian cancer patients. A randomized controlled study should be conducted to confirm the results of this study.Copyright © 2016 Elsevier Inc. All rights reserved.

22 keywords...

hide…