• Langenbecks Arch Chir Suppl Kongressbd · Jan 1998

    Comparative Study

    [Effect of pneumoperitoneum on hemodynamics and intestinal integrity in endotoxinemia: CO2 versus helium].

    • U Holthausen, M Nagelschmidt, Z X Fu, H Goost, T Minor, E Neugebauer, and H Troidl.
    • II. Chirurgischer Lehrstuhl, Universität zu Köln, Klinik Köln-Merheim, Ostmerheimer Strasse 200, D-51109 Köln.
    • Langenbecks Arch Chir Suppl Kongressbd. 1998 Jan 1; 115 (Suppl I): 561-4.

    AbstractIn a study in pigs pathophysiological effects of a pneumoperitoneum (PP) established during endotoxemia (2 micrograms/kg b.w./hr) were investigated. In this situation a PP with carbon dioxide (CO2) or helium induces a deterioration of systemic hemodynamics or acid-base-stability. Some of these effects threaten vital stability. PP with either gas causes a mucosal acidosis of the small bowel within the meaning of an impairment of intestinal oxygen supply. A CO2-PP adversely affects the intestinal energy metabolism and leads to significantly increased endotoxin levels in contrast to helium after desufflation of the abdominal cavity. Data of this study at least demand for a careful monitoring, if laparoscopy is performed in septic and critically ill patients.

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