• Nicholas J Johnson, Babette Rosselot, Sarah M Perman, Kalani Dodampahala, Munish Goyal, David F Gaieski, and Anne V Grossestreuer.
• Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA; Division of Emergency Medicine, University of Washington, Seattle, WA. Electronic address: nickjjohnson@gmail.com.
• J Crit Care. 2016 Dec 1; 36: 218222218-222.

PurposeThe purpose of the study is to determine the association between hemoglobin concentration (Hgb) and neurologic outcome in postarrest patients.MethodsWe conducted a retrospective cohort study using the Penn Alliance for Therapeutic Hypothermia (PATH) cardiac arrest registry. Inclusion criteria were resuscitated cardiac arrest (inhospital or out of hospital) and an Hgb value recorded within 24 hours of return of spontaneous circulation. The primary outcome was favorable neurologic status at hospital discharge. Survival to hospital discharge was a secondary outcome.ResultsThere were 598 eligible patients from 21 hospitals. Patients with favorable neurologic outcome had significantly higher median Hgb in the first 2 hours (12.7 vs 10.5 g/dL; P<.001) and 6 hours (12.6 vs 10.6 g/dL; P<.001) postarrest. Controlling for age, pulseless rhythm, etiology, location of arrest, receipt of targeted temperature management, hematologic or metastatic malignancy, or preexisting renal insufficiency, there was a significant relationship between Hgb and neurologic outcome within the first 6 hours after arrest (odds ratio, 1.23; 95% confidence interval, 1.09-1.38) and survival to hospital discharge (odds ratio, 1.20; 95% confidence interval, 1.08-1.34).ConclusionHigher Hgb after cardiac arrest is associated with favorable neurologic outcome, particularly within the first 6 hours. It is unclear if this effect is due to impaired oxygen delivery or if Hgb is a marker for more severe illness.Copyright © 2016 Elsevier Inc. All rights reserved.

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