• J. Korean Med. Sci. · Nov 2013

    Randomized Controlled Trial Comparative Study

    A prospective, randomized comparison of promus everolimus-eluting and TAXUS Liberte paclitaxel-eluting stent systems in patients with coronary artery disease eligible for percutaneous coronary intervention: the PROMISE study.

    • Ung Kim, Chan-Hee Lee, Jung-Hwan Jo, Hyun-Wook Lee, Yoon-Jung Choi, Jang-Won Son, Sang-Hee Lee, Jong-Seon Park, Dong-Gu Shin, Young-Jo Kim, Myung-Ho Jeong, Myung-Chan Cho, Jang-Ho Bae, Jae-Hwan Lee, Tae-Soo Kang, Kyung-Tae Jung, Kyung-Ho Jung, Seung-Wook Lee, Jang-Hyun Cho, Won Kim, Seung-Ho Hur, Ki-Sik Kim, Heon-Sik Park, Moo-Hyun Kim, Jin-Yong Hwang, Doo-Il Kim, and Tae-Ik Kim.
    • Division of Cardiology, Yeungnam University Medical Center, Daegu, Korea.
    • J. Korean Med. Sci. 2013 Nov 1; 28 (11): 1609-14.

    AbstractWe aimed comparing two-year clinical outcomes of the Everolimus-Eluting Promus and Paclitaxel-Eluting TAXUS Liberte stents used in routine clinical practice. Patients with objective evidence of ischemia and coronary artery disease eligible for PCI were prospectively randomized to everolimus-eluting stent (EES) or paclitaxel-eluting stent (PES) groups. The primary end-point was ischemia-driven target vessel revascularization (TVR) at 2 yr after intervention, and the secondary end-point was a major adverse cardiac event (MACE), such as death, myocardial infarction (MI), target lesion revascularization (TLR), TVR or stent thrombosis. A total of 850 patients with 1,039 lesions was randomized to the EES (n=425) and PES (n=425) groups. Ischemic-driven TVR at 2 yr was 3.8% in the PES and 1.2% in the EES group (P for non-inferiority=0.021). MACE rates were significantly different; 5.6% in PES and 2.5% in EES (P = 0.027). Rates of MI (0.8% in PES vs 0.2% in EES, P = 0.308), all deaths (1.5% in PES vs 1.2% in EES, P = 0.739) and stent thrombosis (0.3% in PES vs 0.7% in EES, P = 0.325) were similar. The clinical outcomes of EES are superior to PES, mainly due to a reduction in the rate of ischemia-driven TVR.

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