• Junxiong Pang, Yee-Sin Leo, and David C Lye.
• aInstitute of Infectious Diseases and Epidemiology, Tan Tock Seng HospitalbSaw Swee Hock School of Public HealthcYong Loo Lin School of Medicine, National University of SingaporedLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
• Curr Opin Crit Care. 2016 Oct 1; 22 (5): 485-90.

Purpose Of ReviewThis review aims to update and summarize the current knowledge about clinical features, management, and risk factors of adult dengue patients requiring intensive care with consequently higher risk of mortality.Recent FindingsIncreasingly, there are more adult dengue patients who require intensive care. This may be due to a shift in epidemiology of dengue infection from mainly a pediatric disease toward adult disease. In addition, multiorgan dysfunction was observed to be a key risk factor for ICU admission and mortality. This may be due to older adults having preexisting comorbidities that potentially predispose to have multiple severe organ impairment. Interventions remain largely supportive but also require more evidence-based trials and treatment protocols.SummaryThese findings highlight the common clinical manifestations of adult dengue patients and the challenges of clinical management in ICU. Risk factors for prediction of adult dengue patients who require ICU are available, but they lack validation and consistent study design for meta-analysis in future. Early recognition of these risk factors, with close monitoring and prompt clinical management, remains critical to reduce mortality.

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