• Gürkan Ersoy, Ülkümen Rodoplu, Osman Yılmaz, Necati Gökmen, Alper Doğan, Özgür Dikme, Aslı Aydınoğlu, and Okyanus Orhon.
• Department of Emergency Medicine, Dokuz Eylül University Faculty of Medicine, İzmir-Turkey. gurkan.ersoy@ymail.com.
• Ulus Travma Acil Cer. 2016 May 1; 22 (3): 215-23.

BackgroundThe aim of the present study was to evaluate the hemostatic effect of chitosan linear polymer in a sheep model with femoral bleeding.MethodsFollowing induction of anesthesia and intubation of sheep, groin injury was induced to initiate hemorrhage. Animals were randomly assigned to study and control groups. In the control group, absorbent pads were packed on the wound, and pressure was supplied by a weight placed over the dressing. In the study group, chitosan linear polymer was poured onto the bleeding site; absorbent pads and pressure were applied in the same manner. At 5-min intervals, bleeding was evaluated. Primary endpoint was time to hemostasis.ResultsBleeding had stopped by the 1st interval in 5 members of the study group, and by the 2nd interval in 1 member. One sheep was excluded. The bleeding stopped after the 1st interval in 1 member of the control group and after the 2nd interval in 4 members. Bleeding stopped in 2 cases following ligation of the bleeding vessel. Hemostasis was achieved earlier in the study group, compared to the control group, and the difference was statistically significant.ConclusionHemostasis was achieved earlier following application of chitosan linear polymer.

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