• Lennaert C P Borra, Tessa M Bosch, Margriet E van Baar, Jan Dokter, Irma M Oen, and Elisabeth J Ruijgrok.
• Department of Hospital Pharmacy, Maasstad Hospital, Maasstadweg 21, 3079DZ Rotterdam, the Netherlands. Electronic address: BorraL@maasstadziekenhuis.nl.
• Burns. 2016 Dec 1; 42 (8): 1819-1824.

IntroductionPharmacokinetics of drugs can be significantly altered in burn patients. The aim of our study was to validate if the current hospital-wide standard dosage of 7mg/kg total bodyweight gentamicin is sufficient to achieve an adequate prophylactic Cmax (Cmax≥20mg/L).Materials And MethodsA prospective observational cohort pharmacokinetic study was conducted in burn patients undergoing surgical burn wound treatment.Results36/40 (90%) burn patients undergoing surgical burn wound treatment at Rotterdam Burn Centre (Maasstad Hospital), the Netherlands, achieved adequate prophylactic serum concentrations (Cmax≥20mg/L) after a single prophylactic intravenous dose of 7mg/kg total bodyweight gentamicin. Total Body Surface Area (TBSA) burned and total bodyweight were statistically significantly correlated with the Cmax, with correlation coefficients of -0.316, 0.443 and p values of 0.047, 0.004, respectively. Other covariates (age, time after injury, serum creatinine, dose, gender, intensive care admittance) were not statistically significantly correlated. Occurrence of postoperative infection was limited (n=1), no statistically significant difference was observed between patients with a therapeutic and patients with a subtherapeutic serum concentration.ConclusionThe current hospital-wide standard dosage of 7mg/kg total bodyweight is sufficient to achieve an adequate prophylactic Cmax in burn patients undergoing surgical burn wound treatment.Copyright © 2016 Elsevier Ltd and ISBI. All rights reserved.

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