• Clin. Exp. Allergy · Feb 2016

    Review

    Mast cells in asthma--state of the art.

    • P Bradding and G Arthur.
    • Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK.
    • Clin. Exp. Allergy. 2016 Feb 1; 46 (2): 194-263.

    AbstractMast cells (MCs) play a central role in tissue homoeostasis, sensing the local environment through numerous innate cell surface receptors. This enables them to respond rapidly to perceived tissue insults with a view to initiating a co-ordinated programme of inflammation and repair. However, when the tissue insult is chronic, the ongoing release of multiple pro-inflammatory mediators, proteases, cytokines and chemokines leads to tissue damage and remodelling. In asthma, there is strong evidence of ongoing MC activation, and their mediators and cell-cell signals are capable of regulating many facets of asthma pathophysiology. This article reviews the evidence behind this. © 2015 John Wiley & Sons Ltd.

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