The Physiologic Basis of Burn Shock and the Need for Aggressive

Critical care clinics · Oct 2016

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The Physiologic Basis of Burn Shock and the Need for Aggressive Fluid Resuscitation.

Burn trauma in the current age of medical care still portends a 3% to 8% mortality. Of patients who die from their burn injuries, 58% of deaths occur in the first 72 hours after injury, indicating death from the initial burn shock is still a major cause of burn mortality. Significant thermal injury incites an inflammatory response, which distinguishes burns from other trauma. This article focuses on the current understanding of the pathophysiology of burn shock, the inflammatory response, and the direction of research and targeted therapies to improve resuscitation, morbidity, and mortality.

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- Lisa Rae, Philip Fidler, and Nicole Gibran.
- Department of Trauma, Surgical Critical Care and Emergency General Surgery, Vanderbilt University Medical Center, 1211 21st Avenue South, MAB 404, Nashville, TN 37212, USA. Electronic address: Lisa.Rae@vanderbilt.edu.
- Crit Care Clin. 2016 Oct 1; 32 (4): 491-505.
AbstractBurn trauma in the current age of medical care still portends a 3% to 8% mortality. Of patients who die from their burn injuries, 58% of deaths occur in the first 72 hours after injury, indicating death from the initial burn shock is still a major cause of burn mortality. Significant thermal injury incites an inflammatory response, which distinguishes burns from other trauma. This article focuses on the current understanding of the pathophysiology of burn shock, the inflammatory response, and the direction of research and targeted therapies to improve resuscitation, morbidity, and mortality.Copyright © 2016 Elsevier Inc. All rights reserved.

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The Physiologic Basis of Burn Shock and the Need for Aggressive Fluid Resuscitation.

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