• Sima K Ramratnam, Cynthia M Visness, Katy F Jaffee, Gordon R Bloomberg, Meyer Kattan, Megan T Sandel, Robert A Wood, James E Gern, and Rosalind J Wright.
• 1 University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
• Am. J. Respir. Crit. Care Med. 2017 Mar 1; 195 (5): 674681674-681.

RationaleMaternal depression and prenatal and early life stress may influence childhood wheezing illnesses, potentially through effects on immune development.ObjectivesTo test the hypothesis that maternal stress and/or depression during pregnancy and early life are associated with recurrent wheezing and aeroallergen sensitivity and altered cytokine responses (enhanced type 2 or reduced virus-induced cytokine responses) from stimulated peripheral blood mononuclear cells at age 3 years.MethodsURECA (Urban Environment and Childhood Asthma) is a birth cohort at high risk for asthma (n = 560) in four inner cities. Maternal stress, depression, and childhood wheezing episodes were assessed by quarterly questionnaires beginning at birth. Logistic and linear regression techniques were used to examine the relation of maternal stress/depression to recurrent wheezing and peripheral blood mononuclear cell cytokine responses at age 3 years.Measurements And Main ResultsOverall, 166 (36%) children had recurrent wheeze at age 3 years. Measures of maternal perceived stress at Years 2 and 3 were positively associated with recurrent wheeze (P < 0.05). Maternal depression (any year) was significantly associated with recurrent wheezing (P ≤ 0.01). These associations were also significant when considered in a longitudinal analysis of cumulative stress and depression (P ≤ 0.02). Neither stress nor depression was significantly related to aeroallergen sensitization or antiviral responses. Contrary to our original hypothesis, prenatal and Year 1 stress and depression had significant inverse associations with several type 2 cytokine responses.ConclusionsIn urban children at high risk for asthma, maternal perceived stress and depression were significantly associated with recurrent wheezing but not increased atopy or reduced antiviral responses.

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