• Nienke J Vet, Saskia N de Wildt, Carin W M Verlaat, Miriam G Mooij, Dick Tibboel, Matthijs de Hoog, Corinne M P Buysse, and Stichting Kinder Intensive Care (Dutch collaborative PICU research network).
• 1Intensive Care, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.2Department of Pediatrics, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.3Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.4Intensive Care, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
• Pediatr Crit Care Me. 2016 Nov 1; 17 (11): e513-e520.

ObjectiveOur earlier pediatric daily sedation interruption trial showed that daily sedation interruption in addition to protocolized sedation in critically ill children does not reduce duration of mechanical ventilation, length of stay, or amounts of sedative drugs administered when compared with protocolized sedation only, but undersedation was more frequent in the daily sedation interruption + protocolized sedation group. We now report the preplanned analysis comparing short-term health-related quality of life and posttraumatic stress symptoms between the two groups.DesignPreplanned prospective part of a randomized controlled trial.SettingTwo tertiary medical-surgical PICUs in the Netherlands.PatientsCritically ill children requiring mechanical ventilation.InterventionsNone.Measurements And Main ResultsEight weeks after a child's discharge from the PICU, health-related quality of life was assessed with the validated Child Health Questionnaire and, only for children above 4 years old, posttraumatic stress was assessed with the Dutch Children's Responses to Trauma Inventory. Additionally, health-related quality of life of all study patients was compared with Dutch normative data. Of the 113 patients from two participating centers in the original study, 96 patients were eligible for follow-up and 64 patients were included (response rate, 67%). No difference was found with respect to health-related quality of life between the two study groups. None of the eight children more than 4 years old showed posttraumatic stress symptoms.ConclusionsDaily sedation interruption in addition to protocolized sedation for critically ill children did not seem to have an effect on short-term health-related quality of life. Also in view of the earlier found absence of effect on clinical outcome, we cannot recommend the use of daily sedation interruption + protocolized sedation.

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