• Crit Care · Sep 2016

    Editorial

    Do we need new prokinetics to reduce enteral feeding intolerance during critical illness?

    • Arthur Raymond Hubert van Zanten.
    • Department of Intensive Care Medicine, Gelderse Vallei Hospital, Willy Brandtlaan 10, 6716 RP, Ede, The Netherlands. zantena@zgv.nl.
    • Crit Care. 2016 Sep 24; 20 (1): 294.

    AbstractGastrointestinal feeding intolerance and critical illness-associated gastric motility dysfunction are common. Although recent guidelines recommend not interrupting gastric feeding when gastric residual volume (GRV) is lower than 500 mL or to completely abandon measurement of GRV, it may seem that the relevance of prokinetics is reduced.In patients at risk for aspiration and in multimodal strategies to enhance feeding performance, however, use of prokinetics is still advocated. Metoclopramide and erythromycin are commonly used promotility agents, although with relevant side effects.Potential targets for new agents and early study results are addressed.

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