• Neda Razaz, K S Joseph, W Thomas Boyce, Martin Guhn, Barry Forer, Robert Carruthers, Ruth Ann Marrie, and Helen Tremlett.
• School of Population and Public Health and Department of Obstetrics & Gynaecology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
• Mult. Scler. 2015 Dec 18.

BackgroundExposure to parental chronic illness is associated with adverse developmental outcomes.ObjectiveWe examined the association between parental multiple sclerosis (MS) and parental MS-related clinical factors on developmental health.MethodsWe conducted a population-based cohort study in British Columbia, Canada, using linked health databases. The outcome was childhood development at 5 years of age, expressed as vulnerability on the Early Development Instrument (EDI). Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression.ResultsMS-affected parents (n = 783) were older, more likely to be English speakers, and had higher rates of mental health morbidity (39.6% vs 22.2%, p < 0.001) than unaffected parents (n = 2988). In the adjusted models, children of mothers with MS (aOR = 0.62, 95% CI = 0.44-0.87), but not children of the fathers with MS, had a lower risk of vulnerability on the social development domain of the EDI. However, mental health comorbidity (aOR = 1.62, 95% CI = 1.05-2.50) and physical comorbidity (aOR = 1.67, 95% CI = 1.05-2.64) among mothers with MS were associated with increased vulnerability on the EDI.ConclusionMaternal MS, but not paternal MS, was associated with lower rates of developmental vulnerability on the social development domain. However, mental and physical comorbidity among MS-affected mothers were associated with increased developmental vulnerability in children.© The Author(s), 2015.

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