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Comment
Blood Measurement of Carcinoembryonic Antigen Level for Detecting Recurrence of Colorectal Cancer.
- Brian D Nicholson, Bethany Shinkins, and David Mant.
- University of Oxford, Oxford, England.
- JAMA. 2016 Sep 27; 316 (12): 1310-1.
Clinical QuestionWhat is the trade-off between sensitivity and specificity at specific carcinoembryonic antigen (CEA) thresholds for detecting recurrent colorectal cancer?Bottom LineTo detect colorectal cancer recurrence, the sensitivity of CEA ranges from 68% for a threshold of 10 µg/L to 82% for a threshold of 2.5 µg/L and the specificity ranges from 97% for a threshold of 10 µg/L to 80% for a threshold of 2.5 µg/L.
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