• J Intensive Care Med · Nov 2012

    Case Reports

    Dilated and unreactive pupils and burst-suppression on electroencephalography due to buproprion overdose.

    • Jyoti Pathria Mundi, Jaime Betancourt, Omar Ezziddin, Brandie Tremayne, Tamara Majic, and Zab Mosenifar.
    • Department of Internal Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
    • J Intensive Care Med. 2012 Nov 1; 27 (6): 384-8.

    AbstractBurst-suppression pattern on electroencephalography (EEG) occurs upon dissociation of the cortex from underlying brain structures. Unless the pattern is a physiologic consequence of administered sedatives, this electroencephalographic pattern is indicative of a poor neurologic outcome and high mortality. We report a case of a 29-year-old female thought to be brain dead based on initial physical examination and EEG findings of burst-suppression, who was later found to have supratherapeutic serum levels of bupropion. This is the second documented case of burst-suppression pattern on EEG in a patient who overdosed on bupropion. We propose that burst-suppression in the setting of bupropion toxicity may revert with drug clearance.

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