• QiaoDong Huang, XiaoMing Liu, JinSheng Chen, CunJu Bao, DongYang Liu, ZeZang Fang, XiaoYu Liang, ZhenHe Lu, and Li Wan.
• Department of Pain Management, The State Key Clinical Specialty for Pain Medicine, The Second Affiliated hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
• Pain Physician. 2016 Sep 1; 19 (7): E1041-7.

BackgroundTrigeminal neuralgia (TN) is a pain appearing in the ophthalmic (V1), maxillary (V2), and mandibular (V3) trigeminal branches. Pharmacologic treatment is the first line for TN; however, many patients prefer to receive minimally invasive treatment rather than medicine because of intolerable side effects. Thermocoagulation radiofrequency (TRF) is a minimally invasive treatment that has been shown to effectively treat the maxillary (V2) and mandibular (V3) divisions, but the safety of TRF treatment of the ophthalmic (V1) division has been controversial.ObjectiveThis study was to observe the effectiveness and safety of TRF treatment of the ophthalmic (V1) division of trigeminal branches in idiopathic TN patients.Study DesignAn observational study.SettingAll of patients received temperature controlled TRF, the effectiveness and safety of TRF was assessed by VAS and complications.MethodsEighty patients with ophthalmic division (V1) or ophthalmic division (V1) combined with maxillary (V2) or mandibular (V3) divisions of idiopathic TN were treated with step-increased temperature TRF for 6 minutes. At a pulse width of 20 ms, the temperature was titrated up 2 degrees from 60 degrees to 66 degrees every 60 seconds, and then another 66 degrees or 68 degrees for 2 minutes. Meanwhile, the tip of the cannula was turned 180 degrees with each temperature titration. Patients were assessed for pain relief and corneal reflex, numbness, and masticatory muscle weakness at one week, one month, and 3 months after the procedure.ResultsEighty patients were successfully treated with temperature controlled TRF for ophthalmic (V1) division. Excellent pain relief was achieved in 79 of 80 patients (98.75%) after one week, one month, and 3 months, and 78 of 80 patients (97.5%) patients experienced tolerable numbness. Only one patient lost the corneal reflex, 14 experienced a corneal reflex that was mildly decreased, and 2 patients felt a foreign body sensation in the ipsilateral eye after TRF, but there were no corneal ulcers, incidences of blindness, or other complications.LimitationsThis study is limited by being an observation study and a non-prospective trial with a short-term follow-up period.ConclusionTemperature controlled TRF to the ophthalmic division (V1) of the semilular ganglion is effectiveness and safe in TN.Key WordsThermocoagulation radiofrequency, pulsed radiofrequency, trigeminal neuralgia, ophthalmic division, trigeminal ganglion, pain, numbness, corneal reflex.

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