• J Clin Epidemiol · Apr 2016

    A reduced factor structure for the PROQOL-HIV questionnaire provided reliable indicators of health-related quality of life.

    • Christophe Lalanne, Olivier Chassany, Patrizia Carrieri, Fabienne Marcellin, Andrew R Armstrong, France Lert, Bruno Spire, Rosemary Dray-Spira, and Martin Duracinsky.
    • University Paris Diderot, Paris Sorbonne Cité, EA 7334 (REMES), Patient-Centered Outcomes Research, Paris, France; AP-HP, Hôtel-Dieu Hospital, URC ECO, 1 Place du Parvis Notre-Dame, 75004, Paris, France. Electronic address: ch.lalanne@gmail.com.
    • J Clin Epidemiol. 2016 Apr 1; 72: 116-25.

    ObjectivesTo identify a simplified factor structure for the PROQOL-human immunodeficiency virus (HIV) questionnaire to improve the measurement of the health-related quality of life (HRQL) of HIV-positive patients in clinical care and research settings.Study Design And SettingHRQL data were collected using the eight-dimension PROQOL-HIV questionnaire from 2,537 patients (VESPA2 study). Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) validated a simpler four-factor structure and assessed measurement invariance (MI). Multigroup analysis assessed the effect of sex, age, and antiretroviral therapy (ART) on the resulting factor scores. Correlations with symptom and Short Form (SF)-12 self-reports assessed convergent validity.ResultsItem analysis, EFA, and CFAs confirmed the validity [comparative fit index (CFI), 0.948; root mean square error of approximation, 0.064] and reliability (α's ≥ 0.8) of four dimensions: physical health and symptoms, health concerns and mental distress, social and intimate relationships, and treatment-related impact. Strong MI was demonstrated across sex and age (decrease in CFI <0.01). A multiple-cause multiple-indicator model indicated that HRQL correlated as expected with sex, age, and the ART status. Correlations of HRQL, symptom reports, and SF-12 scores evidenced convergent validity criterion.ConclusionThe simplified factor structure and scoring scheme for PROQOL-HIV will allow clinicians to monitor with greater reliability the HRQL of patients in clinical care and research settings.Copyright © 2016 Elsevier Inc. All rights reserved.

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