• Atsushi Sawada, Yusuke Yoshikawa, Masanori Yamauchi, Akihiko Watanabe, and Michiaki Yamakage.
• Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo 060-8543.
• Masui. 2012 Apr 1; 61 (4): 358-63.

BackgroundWe investigated the efficacy of glucose infusion for the inhibition of breakdown of fat tissue and muscle protein under remifentanil anesthesia.MethodsTwenty adult patients (ASA I or II) were enrolled in this study and randomized into two groups: a control group receiving acetated Ringer's solution without glucose (n = 10) and a glucose group receiving acetated Ringer's solution containing 1% glucose (n = 10). Anesthesia was induced by propofol and fentanyl and maintained by sevoflurane and remifentanil. Plasma concentrations of glucose and cortisol were measured. Acetoacetic acid and 3-hydroxybutyrate acid were measured as parameters for breakdown of fat tissue. Urine 3-methylhistidine/plasma creatinine was measured as a parameter for breakdown of muscle protein during surgery. Data were analyzed by the unpaired t-test, Friedman's chi2-test, Wilcoxon's t-test and Mann-Whitney U test. P < 0.05 was considered significant.ResultsPlasma concentrations of cortisol and glucose were not increased in either group during the study. Plasma concentrations of acetoacetic acid and 3-hydroxybutyrate acid and urine 3-methylhistidine/plasma creatinine significantly increased in the control group but did not increase in the glucose group.ConclusionsInfusion of glucose suppresses breakdown of fat tissue and muscle protein under remifentanil anesthesia.

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