• Harefuah · Dec 1991

    Case Reports

    [Lithium carbonate augmentation in tricyclic antidepressant-resistant depression].

    • A Dorevitch and Y Ginath.
    • Talbieh Mental Health Center, Jerusalem.
    • Harefuah. 1991 Dec 1; 121 (11): 429-30.

    AbstractCombinations of lithium carbonate and tricyclic antidepressants are effective in the treatment of resistant unipolar depression. We present a case in which addition of lithium carbonate to a maximal dose of desipramine provided rapid and sustained improvement in a severely depressed 57-year-old woman. She had previously failed to respond to maximum doses of antidepressant drugs of 2 different classes. Although the lithium-tricyclic combination was successful in our case, we caution against its routine use.

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