• Patompong Ungprasert, Cynthia S Crowson, and Eric L Matteson.
• Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN. Electronic address: p.ungprasert@gmail.com.
• Chest. 2017 Feb 1; 151 (2): 425-430.

ObjectiveThe goal of this study was to investigate the risk of VTE among patients with sarcoidosis.MethodsA cohort of 345 incident cases of sarcoidosis and 345 sex- and age-matched comparator subjects in Olmsted County, Minnesota, from 1976 to 2013 were identified from the comprehensive medical record linkage system. Medical records were reviewed for DVT and pulmonary embolism (PE). The cumulative incidence was estimated, adjusted for the competing risk of death. Cox proportional hazards models were used to compare the rate of development of these events between patients with sarcoidosis and the nonsarcoidosis comparison cohort.ResultsThe prevalence of VTE, DVT, and PE prior to the index date was not significantly different between case and comparator subjects. The risk of incident VTE adjusted for age, sex, and calendar year was significantly higher among patients with sarcoidosis (hazard ratio [HR], 3.04 [95% CI, 1.47-6.29]). Significantly elevated risk was observed in both subtypes of VTE, with an HR of 3.14 (95% CI, 1.32-7.48) for DVT and an HR of 4.29 (95% CI, 1.21-15.23) for PE. A sensitivity analysis including only VTE events that occurred at least 6 months after the index date adjusted for age, sex, and calendar year revealed somewhat lower HRs: VTE, 2.73 (95% CI, 1.30-5.72); DVT, 3.00 (95% CI, 1.25-7.20); and PE, 3.58 (95% CI, 0.98-13.03).ConclusionsAn increased risk of VTE among patients with sarcoidosis was observed in this population-based cohort.Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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