• M Heesen, M Klimek, R Rossaint, G Imberger, and S Straube.
• Department of Anaesthesia, Kantonsspital Baden, Baden, Switzerland.
• Anaesthesia. 2016 Dec 1; 71 (12): 1471-1481.

AbstractWe examined whether paravertebral block has an effect on the prevalence of persistent postsurgical pain after breast surgery. Seven randomised, controlled trials (559 patients) which had the outcome assessor blinded were included, comparing patients who received paravertebral blocks after breast surgery with patients who did not. The risk ratio (95% CI) was 0.75 (0.48-1.15) for the incidence of postoperative pain at 3 months (four studies, 317 patients); the risk ratio (95% CI) obtained from three studies including 301 patients reporting on pain after 6 months was 0.57 (0.29-1.72), and the risk ratio (95% CI) for pain after 12 months (three trials, 237 patients) was 0.42 (0.15-1.23). Conventional meta-analysis using the random effects model thus showed no statistically significant risk reduction for persistent postoperative pain at 3 months, 6 months or 12 months. Trial sequential analysis, used to consider the risk of type 1 and type 2 random error, showed that at 3 months, 6 months and 12 months, the number of subjects in the analyses were only 18.3%, 6.8% and 4.2% of the required information sizes at those time points, respectively. Our study is the first to evaluate data on pain 12 months postoperatively. Trial sequential analysis revealed that the current evidence is not sufficient to reach a conclusion. These findings stand in contrast to previous meta-analyses with fewer studies that had concluded that paravertebral block effectively reduces chronic pain.© 2016 The Association of Anaesthetists of Great Britain and Ireland.

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