• Pain Med · Dec 2013

    Review

    Mitigating GI risks associated with the use of NSAIDs.

    • Mahnaz Momeni and James D Katz.
    • Department of Rheumatology, The George Washington University, Washington, District of Columbia, USA.
    • Pain Med. 2013 Dec 1;14 Suppl 1:S18-22.

    ObjectiveNonsteroidal anti-inflammatory drugs (NSAIDs) have multiple established adverse effects on various organ systems. Among those associated with high mortality are gastrointestinal complications. We address the scope of the problem and the scientific basis for risk mitigation.DesignThis review covers the most successful of such strategies published to date.ResultsMitigation strategies to enable ongoing anti-inflammatory benefit are well studied, albeit imperfect.ConclusionsSuch strategies may involve the choice of NSAID or the combined use of gastroprotective measures in association with NSAIDs.Wiley Periodicals, Inc.

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