• David Thomson, Timothy Cowan, Conrad Loten, Christina Botfield, Elizabeth Holliday, and John Attia.
• Emergency Department, John Hunter Hospital, Newcastle, New South Wales, Australia.
• Emerg Med Australas. 2017 Feb 1; 29 (1): 33-39.

ObjectiveHypoxia is a recognised complication of procedural sedation. This study sought to determine whether there was an association between the use of high-flow oxygen delivery by a non-rebreather (NRB) mask during ED procedural sedation and decreased rates of hypoxia when compared with alternative oxygenation methods.MethodsRecords of all procedural sedations performed over a 12 month period in an Australian tertiary ED were reviewed retrospectively. The primary outcome was whether recorded oxygen saturations fell below 90%. Specifics of the oxygen delivery method were noted and data collected included sex, age, indication for sedation, drugs and doses administered, time of day sedation was commenced and staff grade of sedationist.ResultsA total of 755 procedural sedations were reviewed. Two hundred and five (27.1%) patients were administered oxygen via NRB mask from the outset of their sedation. NRB administration was associated with a statistically significant decreased rate of hypoxia (1/205 patients vs 23/550 [odds ratio: 0.112; 95% confidence interval: 0.003-0.0702]; P = 0.0090). This association remained statistically significant when adjusted for confounders.ConclusionsThis study demonstrates an association with a statistically significant reduction in hypoxia when high-flow oxygen via NRB mask is administered during emergency procedural sedation. This intervention is simple, safe and inexpensive, and we would advocate that it be evaluated further in prospective trials.© 2016 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine.

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