• Pain Med · Mar 2012

    Dual-opioid therapy: changing the paradigm. Introduction.

    • Bruce D Nicholson.
    • Pain Med. 2012 Mar 1;13 Suppl 1:S1-3.

    IntroductionMorphine sulfate and oxycodone hydrochloride are commonly used for pain management because of their pharmacologic profile, pharmacokinetics, and analgesic potency. However, opioids are associated with a significant adverse event (AE) burden that limits their use in both the acute and the chronic pain settings.SummaryCo-administration of opioids demonstrated synergistic analgesia and reduced side effects. Thus, dual-opioid therapy has the potential to enhance the positive analgesic benefits of opioids, while limiting the burden of opioid-related AEs. This symposium proceedings was based on presentations at the 13th World Congress on Pain in August 2010.ConclusionsThis program will review the rationale for dual-opioid therapy based on preclinical findings and data from clinical studies showing the efficacy and tolerability profile of a dual-opioid formulation when used to treat acute postoperative pain.Wiley Periodicals, Inc.

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