• Am J Emerg Med · Jan 2017

    Case Reports

    Glucagon for refractory asthma exacerbation: a case series.

    • Jillian M Cavallari, Tara S Jawaro, Nadia I Awad, and Patrick J Bridgeman.
    • Department of Pharmacy, Robert Wood Johnson University Hospital, New Brunswick, NJ; Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ.
    • Am J Emerg Med. 2017 Jan 1; 35 (1): 144-145.

    AbstractGlucagon, a hormone secreted by pancreatic alpha cells, causes bronchial smooth muscle relaxation by activating the synthesis of cyclic adenosine monophosphate. It was studied in the 1980s and 1990s as a treatment option for the management of asthma but has since not been evaluated. Data to support its use are limited, but it may serve as a last-line agent for refractory asthma exacerbation. Here we describe 4 cases in which intravenous glucagon was used to manage severe, refractory asthma exacerbation in the emergency department.Copyright © 2016 Elsevier Inc. All rights reserved.

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