• Wei-Jun Chen, En-Ning Zhang, Zhao-Kun Zhong, Mao-Zhu Jiang, Xi-Feng Yang, Dong-Mei Zhou, and Xiu-Wen Wang.
• Shandong University Jinan 250100, Shandong, China ; Department of Medical Oncology, Yantaishan Hospital Yantai 264000, Shandong, China.
• Int J Clin Exp Patho. 2015 Jan 1; 8 (7): 8671-5.

BackgroundmiR-153 has been found to be significantly decreased in non-small cell lung cancer (NSCLC) tissues; however, its clinical significance has not been investigated.MethodsThe expression patterns of miR-153 in 137 pairs of human lung cancer tissues and adjacent normal lung tissues were analyzed using qRT-PCR. The relationships between miR-153 expression and clinicopathological parameters were examined by chi-square test. Kaplan-Meier method and the log-rank test were used to determine the difference in overall survival (OS) rates between two groups.ResultsThe expression of miR-153 was reduced significantly, compared with adjacent normal lung tissues (P<0.05). We observed that the expression level of miR-153 was positively correlated with the clinical stage (P=0.005), lymph node status (P=0.014), distant metastasis (P=0.004), and differentiated degree (P<0.001) in NSCLC patients. According to the Kaplan-Meier survival analysis, the patients with low miR-153 expression exhibited evidently poorer overall survival rates than those with high miR-153 expression (P=0.003). Multivariate analysis showed that the expression of miR-153 was an independent and significant factor associated with poor OS rates (P=0.002).ConclusionDecreased expression of miR-153 might be a potential unfavorable prognostic factor for patients with NSCLC, and further studies would be needed to prove our findings.

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