• Leon W Herndon, Robert D Williams, Martin Wand, and Sanjay Asrani.
• Duke University Eye Center, Durham, North Carolina 27710, USA. hernd012@mc.duke.edu
• Am. J. Ophthalmol. 2003 May 1; 135 (5): 713-5.

PurposeTo report increased eyelid pigmentation as an adverse side effect associated with topical ocular hypotensive lipids in African Americans.DesignInterventional case series.MethodsTwo African-American patients with open-angle glaucoma are described in whom increased eyelid pigmentation developed 1 month to 5 months after beginning treatment with either latanoprost or bimatoprost.ResultsLatanoprost was discontinued in an African-American patient, and pigmentation gradually diminished by 3 months after cessation of latanoprost. Increased eyelid pigmentation and increased eyelash length were noted in another African-American patient after just 4 weeks on bimatoprost.ConclusionsAn increase in eyelid pigmentation and eyelash growth is a possible complication of topical ocular hypotensive lipid therapy, even in African-American patients. The changes seems to present earlier after bimatoprost treatment then after latanoprost treatment. Cessation of these medications may lead to loss of induced pigmentation.

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